Download JRS Pharma Formulation Handbook PDF

TitleJRS Pharma Formulation Handbook
File Size1.3 MB
Total Pages50
Document Text Contents
Page 1

A Guide for R+D

FORMULATION
HANDBOOK

Page 25

Extract of Cartilage
Direct Compression

Key Words: Very Hygroscopic, Sticky,

Direct Compression

JRS Products: PROSOLV SMCC , EMCOMPRESS ,

ARBOCEL , VIVASOL , PRUV

® ®

® ® TM

90
P 290

FORMULATION
HANDBOOK

Extract of Cartilage is a hygroscopic substance with a very

high water content. The substance is very sticky. The extract

is a product made from the cartilage of the common dogfish

shark. There are several diseases which can affect the carti-

Comments:

Tablet Characteristics

Formulation

Procedure

Tablet weight: 525.0 mg

Tablet diameter: 13 mm

Angle of repose: 44°

Bulk density: 0.49 g/ml

Compaction force: 9.1 kN / 18.4 KN / 22 KN

Hardness: 2.5 kp / 7.3 kp / 9.7 kp

Friability: 0.26 %

Disintegration time: 25 min

Active content (mg) mg/tablet Contribution (%)

186.9 186.9 35.6

e 43.5 8.3

(Silicified Microcrystalline Cellulose) 199.0 37.9

(Calcium Hydrogen Phosphate) 70.3 13.4

(Powdered Cellulose) 5.25 1.0

Talcum 9.45 1.8

( ) 8.0 1.5

(Sodium Stearyl Fumarate) 2.6 0.5

Extract of Cartilage

Ascorbic Acid crystallin

Croscarmellose Sodium

90

P 290

PROSOLV SMCC

EMCOMPRESS

ARBOCEL

VIVASOL

®

®

®

®

PRUVTM

Blending:

Tablet press: Korsch EK 0 excentric press, 13 mm punch

Hardness tester: Schleuniger 2E

Disintegration tester: Pharmatest Standard PTZ

Friability tester: Pharmatest PTF

Equipment:

lage, for example rthritis.

It was possible to develop a simple formulation with

a

Silicified Microcrystaline Cellulose in Direct Compres-

sion.

PROSOLV

SMCC®

4
2
8
2
_
0
0
8

.E
1
.0

0
6
0
3
k
u

Extract of Cartilage, Ascorbic Acid, and were blended for 15 minutes. ,

Talcum and were added and blended for another 10 minutes. After that was added and mixed for 3 minutes.

PROSOLV SMCC EMCOMPRESS ARBOCEL

VIVASOL PRUV

® ® ®

® TM

90 P 290

Disclaimer: The information provided is based on thorough research and is believed to be completely reliable. Application suggestions are
given to assist our customers, but are for guidance only. Circumstances in which our material is used vary and are beyond our control.
Therefore, we cannot assume any responsibility for risks or liabilities, which may result from the use of this technical advice.

Page 1/1

# 4282-008

JRS PHARMA LP

Customer Service:

JRS PHARMA GMBH+CO.KG
2981 Route 22, Suite 1
Patterson, NY 12563-2359
Toll-Free: (800) 431-2457
Phone: +1 (845) 878-3414
Fax: +1 (845) 878-3484
E-mail: [email protected]
www.jrspharma.com

Holzmühle 1
D-73494 Rosenberg (Germany)
Phone: + 49 (0) 79 67 / 1 52-0
Fax: + 49 (0) 79 67 / 1 52-345
E-mail: [email protected]
www.jrspharma.de
www.jrs.de

WORLDWIDE HEADQUARTERS

Customer Service: +49 (0) 7967 / 152-312

USA + CANADA

+1 (845) 878-3414

Page 49

Simethicone
Direct Compression

Key Words: L A P F

D C C T

iquid ctive, oor lowability,

irect ompression, hewable ablets

JRS Products: EMDEX , EMCOMPRESS , PRUV® ® TM

FORMULATION
HANDBOOK

Simethicone is used to treat the symptoms of gas such as

uncomfortable or painful pressure, fullness, and bloating.

Comments:

Tablet Characteristics

Formulation

Procedure

Tablet weight: 500.0 mg

Tablet diameter: 13 mm

Compaction force: 26 kN

Hardness: 5.8 kp

Simethicone was dispersed in and blended for 10 minutes. Then was added and blended again

for 5 minutes. After that Sodium Stearyl Fumarate was added and blended for 3 minutes.

EMDEX

PRUV

®

TM

EMCOMPRESS®

Active content (mg) mg/tablet Contribution (%)

50.0 50.0 10.0

150.0 30.0

(Calcium Hydrogen Phosphate) 295.0 59.0

(Sodium Stearyl Fumarate) 5.0 1.0

Simethicone

EMCOMPRESS®
EMDEX

PRUV

®

TM

(Dextrates)

Blending:

Tablet press: Korsch EK 0 excentric press, 13 mm punch

Hardness tester: Schleuniger 2E

Equipment:

It can be directly compressed using EMDEX EMCOM-

PRESS EMDEX

®

® ®

and

as binders. is a watersoluble binder for

chewable tablets.

4
2
8
2
_
0
2
1

.E
1
.0

0
6
0
3
k
u

Disclaimer: The information provided is based on thorough research and is believed to be completely reliable. Application suggestions are
given to assist our customers, but are for guidance only. Circumstances in which our material is used vary and are beyond our control.
Therefore, we cannot assume any responsibility for risks or liabilities, which may result from the use of this technical advice.

Page 1/1

# 4282-021

JRS PHARMA LP

Customer Service:

JRS PHARMA GMBH+CO.KG
2981 Route 22, Suite 1
Patterson, NY 12563-2359
Toll-Free: (800) 431-2457
Phone: +1 (845) 878-3414
Fax: +1 (845) 878-3484
E-mail: [email protected]
www.jrspharma.com

Holzmühle 1
D-73494 Rosenberg (Germany)
Phone: + 49 (0) 79 67 / 1 52-0
Fax: + 49 (0) 79 67 / 1 52-345
E-mail: [email protected]
www.jrspharma.de
www.jrs.de

WORLDWIDE HEADQUARTERS

Customer Service: +49 (0) 7967 / 152-312

USA + CANADA

+1 (845) 878-3414

Similer Documents